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Image Search Results
Journal: Respiratory Research
Article Title: Blood oxygen regulation via P2Y12R expressed in the carotid body
doi: 10.1186/s12931-024-02680-x
Figure Lengend Snippet: Physiological parameters of control groups preceding hypoxic challenge
Article Snippet: ARL 67156 (Cat. No. 1283; PubChem CID: 11957464),
Techniques: Control
Journal: Respiratory Research
Article Title: Blood oxygen regulation via P2Y12R expressed in the carotid body
doi: 10.1186/s12931-024-02680-x
Figure Lengend Snippet: Physiological parameters of experimental groups preceding hypoxic challenge
Article Snippet: ARL 67156 (Cat. No. 1283; PubChem CID: 11957464),
Techniques:
![Glomic P2Y12R, but not centrally expressed receptors or thrombocytes influence chemoreflex in vivo. A – I Experimental animals were treated with clopidogrel (10 mg/kg i.p., 60 min prior to the experiment) ( A – C ); PSB 0739 (0.3 mg/kg i.t., 18 h prior to the experiment) ( D – F ); the mouse specific anti-CD41 antibody (deplete thrombocytes) ( G – I ) or the respective vehicle; and mean arterial pressure, heart rate, oxygen saturation and respiratory rate were recorded during ingravescent hypoxic challenge. Distinct stages of hypoxic environmental challenges are indicated with colors: normoxia ( light blue ), mild hypoxia ( yellow ) severe hypoxia ( red ) and recurrent normoxia (normoxia II., dark blue ). Data represent the mean ± SD. Box-and-whisker diagrams demonstrate statistical differences between control and treatment groups during the identical challenge stage. Data show the median, the minimum and maximum values, and the interquartile range (n = 11 for Clopidogrel; n = 12 for PSB 0739; and n = 10 for platelet depleted) ( A , D , G ). Arterial blood-gas and pH changes are shown for clopidogrel (n = 9) (B), PSB 0739 (n = 8) ( E ) and platelet depleted groups (n = 10) ( H ) compared to the respective control animals (n = 9 for Control (clopidogrel); n = 12 Control (PSB 0739); and n = 10 Control (depleted) groups). Graphs compare the area under curve (AUC) values of breath distension for the clopidogrel (n = 7) ( F ) and platelet depleted experimental groups (n = 5–8) ( I ). *, p ≤ 0.05 [two-way ANOVA with Bonferroni’s post-hoc test ( A , D , G ); one-way ANOVA with Tukey’s post-hoc test ( B , E , H ) and unpaired two-tailed Student’s t -test ( C , F , I )]](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_1555/pmc10821555/pmc10821555__12931_2024_2680_Fig5_HTML.jpg)
Journal: Respiratory Research
Article Title: Blood oxygen regulation via P2Y12R expressed in the carotid body
doi: 10.1186/s12931-024-02680-x
Figure Lengend Snippet: Glomic P2Y12R, but not centrally expressed receptors or thrombocytes influence chemoreflex in vivo. A – I Experimental animals were treated with clopidogrel (10 mg/kg i.p., 60 min prior to the experiment) ( A – C ); PSB 0739 (0.3 mg/kg i.t., 18 h prior to the experiment) ( D – F ); the mouse specific anti-CD41 antibody (deplete thrombocytes) ( G – I ) or the respective vehicle; and mean arterial pressure, heart rate, oxygen saturation and respiratory rate were recorded during ingravescent hypoxic challenge. Distinct stages of hypoxic environmental challenges are indicated with colors: normoxia ( light blue ), mild hypoxia ( yellow ) severe hypoxia ( red ) and recurrent normoxia (normoxia II., dark blue ). Data represent the mean ± SD. Box-and-whisker diagrams demonstrate statistical differences between control and treatment groups during the identical challenge stage. Data show the median, the minimum and maximum values, and the interquartile range (n = 11 for Clopidogrel; n = 12 for PSB 0739; and n = 10 for platelet depleted) ( A , D , G ). Arterial blood-gas and pH changes are shown for clopidogrel (n = 9) (B), PSB 0739 (n = 8) ( E ) and platelet depleted groups (n = 10) ( H ) compared to the respective control animals (n = 9 for Control (clopidogrel); n = 12 Control (PSB 0739); and n = 10 Control (depleted) groups). Graphs compare the area under curve (AUC) values of breath distension for the clopidogrel (n = 7) ( F ) and platelet depleted experimental groups (n = 5–8) ( I ). *, p ≤ 0.05 [two-way ANOVA with Bonferroni’s post-hoc test ( A , D , G ); one-way ANOVA with Tukey’s post-hoc test ( B , E , H ) and unpaired two-tailed Student’s t -test ( C , F , I )]
Article Snippet: ARL 67156 (Cat. No. 1283; PubChem CID: 11957464),
Techniques: In Vivo, Whisker Assay, Control, Two Tailed Test